The Nikkei 225 Index fell 179 points or 0.27 percent on Wednesday to close at 65090 points. Leading the losses are Kyowa Hakko Kirin (-5.25%), Dena (-4.35%) and Sumitomo Dainippon (-4.12%). Top gainers were Furukawa Electric (12.71%), Tokai Carbon (9.08%) and Fujikura (8.58%).